Research progress review on long non-coding RNA in colorectal cancer

Colorectal cancer (CRC) is one of the most common malignancies globally, and morbidity mortality rates associated with it are among highest around world. Not even great advances in colorectal diagnosis treatment technologies have been able to increase 5-year survival rate this disease. Recidivation metastasis main causes death CRC, although underlying mechanism remains unknown. Long non-coding RNA (lncRNA) a type that greater than 200 nt length. LncRNAs involved cell proliferation, apoptosis, metastasis, differentiation. Abnormal expression lncRNAs reported various diseases. Relevant studies demonstrated capable interacting DNAs, RNAs, proteins, thereby regulating Wnt, p53, other signaling pathways playing an important role biogenesis, progression, drug resistance CRC. In present report, recent progress research related reviewed.